![]() ![]() Transgenic mouse models have been instrumental in evaluating the pathophysiology of Alzheimer’s disease (AD), as well as the potential of therapeutic interventions. Also described is a strategy to re-optimize, as dictated by the particular testing environment utilized. This is a frequently used background strain to study the age-dependent effects of mutant P301L tau (rTg(TauP301L)4510 mice) on the memory deficits associated with Alzheimer’s disease. Here, a MWM protocol tailored for use with the F1 FVB/N x 129S6 background is described. ![]() ![]() Failure to tailor the MWM protocol to the background strain of the mouse model may lead to under- or over- training, thereby masking group differences in probe trials. To ensure differences between transgene negative and transgene positive mice can be detected, identification of a training procedure sensitive to the background strain is essential. However, the background strain of the mouse model used can have a substantial effect on the observed behavioral phenotype, with some strains exhibiting superior learning ability relative to others. The Morris water maze (MWM) is a commonly used task to assess hippocampal-dependent spatial learning and memory in transgenic mouse models of disease, including neurocognitive disorders such as Alzheimer’s disease. ![]()
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